Tiger BioSciences Highlights Key Findings from Study on Multi-Layer Placental Allografts

CONSHOHOCKEN, Pa., Nov. 28, 2025 /PRNewswire/ -- Tiger BioSciences is highlighting a foundational research study published in the International Journal of Molecular Sciences that examines 2-, 3-, and 4-layer placental-derived allografts and their biochemical composition.

The human placenta has been valued in clinical wound care for its extracellular matrix (ECM), collagen content, and growth factors. Tiger BioSciences offers advanced allograft technologies in multiple configurations: a two-layer amnion, a full thickness placental membrane (amnion, intermediate layer, and chorion), and a four-layer construct (full thickness tissue plus additional amnion).

Key Research Findings

• All three allograft configurations retained original placental membrane characteristics
• 4-layer allografts contained collagen levels twice as high as 2- and 3-layer versions
• 3- and 4-layer allografts showed more abundant ECM components including elastin, proteoglycans, and hyaluronic acid
• Key proteins (ANG-2, EGF, PDGF-AA, VEGF) were present in all constructs, with higher retention in 3- and 4-layer designs

"Each layer of preserved placental tissue is rich in ECM, collagens and key native proteins," noted Garrett Grinsfelder, President of Tiger Wound Care, emphasizing the structural composition's importance in allograft effectiveness.

About Tiger BioSciences

Tiger BioSciences is a vertically integrated cell and tissue technology company specializing in Cellular, Acellular, Matrix-like Products (CAMPs) recovery, processing, technology development, and distribution for wound care applications.

References

Singh, P., et al. (2025). Comparative Study of Placental Allografts with Distinct Layer Composition. *International Journal of Molecular Sciences*, 26(7), 3406.

SOURCE Tiger BioSciences